Advances in Spinal Fusion: Molecular Science, BioMechanics, by Kai-Uwe Lewandrowski

By Kai-Uwe Lewandrowski

Advances in Spinal Fusion unearths a brand new iteration of fabrics and units for superior operations in spinal fusion. This reference showcases rising learn and applied sciences in components akin to biodegradable implants, drug supply, stem mobile isolation and transfection, mobilephone encapsulation and immobilization, and the layout of 2nd and 3D scaffolds for cells. It captures a cascade of ideas the most important to elevated therapeutic and reduced morbidity in spinal fusion equipment and mechanics and addresses present criteria in analytical technique and qc, it describes the choice of biomaterials for superior biocompatibility, biostability, and structure/function relationships.

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Such more ‘‘biocompatible’’ cements may eliminate concerns about thermal necrosis and cytotoxicity and appear to result in mechanical stabilization of fractured VBs similar to that of PMMA [47,58,74]. Yet, if thermal and toxicity mechanisms are determined to play a role in pain relief, then the non-PMMA cements may not be as effective. The bioresorbable cements are appealing for use in prophylactic augmentation and in younger patients [76] because injected VBs would be mechanically augmented immediately and theoretically provide an osteoconductive material for subsequent bone repair and remodeling [75].

Experimental vertebroplasty using osteoconductive granular material. Spine 2000; 25:1070–1076. 76. Verlaan JJ, van Helden WH, Oner FC, Verbout AJ, Dhert WJ. Balloon vertebroplasty with calcium phosphate cement augmentation for direct restoration of traumatic thoracolumbar vertebral fractures. Spine 2002; 27:543–548. A. A. I. INTRODUCTION Spine care is trending towards procedures that are less invasive and motion sparing. Among the most innovative are kyphoplasty and vertebroplasty for the treatment of osteoporotic vertebral compression fractures (VCFs).

Mater. Sci. Mater. Med 2002; 13:1–5. 63. Cotten A, Boutry N, Cortet B, Assaker R, Demondion X, Leblond D, Chastanet P, Duquesnoy B, Deramond H. Percutaneous vertebroplasty: state of the art. Radiographics 1998; 18:311–323. 64. Deramond H, Depriester C, Toussaint P, Galibert P. Percutaneous vertebroplasty. Semin. Musculoskelet. Radiol 1997; 1:285–295. 65. Jasper LE, Deramond H, Mathis JM, Belkoff SM. The effect of monomer-to-powder ratio on the material properties of Cranioplastic. Bone 1999; 25:27S–29S.

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