By Roger J. Laham, Donald S. Baim
An interdisciplinary panel of pioneers and opinion leaders evaluate the elemental, preclinical, medical, and developmental pathways to new therapy innovations, equivalent to healing angiogenesis and myogenesis. The authors benefit from new organic figuring out, novel healing ambitions, a number of to be had and well-studied healing thoughts, and the required imaging strategies to degree results. Their in-depth discussions hide the id of latest healing objectives and pathways, the research of transcriptional components, grasp swap molecules, cell-based techniques, chemokines, a greater figuring out of the results of getting older, endothelial disorder, and hypercholesterolemia in keeping with angiogenic stimuli. Highlights comprise exam of drug supply difficulties, results degree, stem treatment, high-risk interventions, improvement pathways, and destiny chances.
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Extra resources for Angiogenesis and Direct Myocardial Revascularization (Contemporary Cardiology)
J Cell Sci 2003;116:665–674. 26. Rudders S, Gaspar J, Madore R, et al. ESE-1 is a novel transcriptional mediator of inflammation that interacts with NF-kappa B to regulate the inducible nitric-oxide synthase gene. J Biol Chem 2001;276:3302–3309. 27. Schreiber M, Wang Z, Jochum W, Fetka I, Elliott C, Wagner EF. Placental vascularisation requires the AP-1 component fra1. Development 2000;127:4937–4948. 28. Kuo CT, Veselits ML, Barton KP, Lu MM, Clendenin C, Leiden JM. The LKLF transcription factor is required for normal tunica media formation and blood vessel stabilization during murine embryogenesis.
Most notably, there is a reduction in the number of differentiated smooth muscle cells and pericytes. These defects result in aneurysmal dilatation of the large vessels and eventual rupture with intra-amniotic hemorrhage (28). A similar phenotype was recently reported for mice lacking the cytoplasmic domain of Ephrin B2, suggesting that signaling through ephrin B2 may involve activation of LKLF or similar transcription factors during later stages of blood vessel development (44). The bHLH transcription factor dHAND has recently been shown to be crucial for yolk sac vascular development.
Alternatively, several of these newly identified transcription factors could serve as targets for inhibiting blood vessel development or angiogenesis. Drugs used to augment or interfere with the function of these factors could enhance the development of angiogenesis in diseases such as ischemic heart disease, where the development of new blood vessel development may be beneficial. Downregulation or blockade of the function of these factors might also be effective in inhibiting the angiogenesis that promotes such diseases as cancer, rheumatoid arthritis, or diabetic retinopathy.