Small-Animal SPECT Imaging by Matthew A. Kupinski, Harrison H. Barrett

By Matthew A. Kupinski, Harrison H. Barrett

Small-Animal SPECT Imaging is an edited paintings derived from the 1st workshop on Small-Animal SPECT Imaging held January 14-16, 2004 on the collage of Arizona, Tucson, AZ, united states. the final objective of the assembly and consequently this quantity is to advertise details alternate and collaboration among the examine teams constructing platforms for small-animal functions. subject matters comprise the biomedical importance of small-animal imaging, an summary of detector applied sciences together with scintillation cameras and semi-conductor arrays, imager layout and knowledge acquisition structures, animal dealing with and anesthesia matters, aim evaluation of snapshot caliber, and procedure modeling and reconstruction algorithms.

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2). The question then arises as to how to specify and compare the resolutions of these two distinct kinds of detectors. The common approach is to use the segment size as the resolution measure in pixellated detectors and the full width at half maximum (FWHM) of the detector PSF as the measure for monolithic detectors. This approach is unsatisfactory for two reasons. First, it takes no account of the task the system is expected to perform. Second, the distinction between the two kinds of detector is really a false dichotomy.

In the absence of noise, the mth detector element records a measurement given by d3 r f (r)hm (r). 1) S where r is a 3D vector, f (r) is the object activity, S is the region of support of the object, and hm (r) is the sensitivity function that specifies the response of the detector to radiation emanating from point r. If the detector can "see" the object 15 Detectors for Small-Animal SPECT I through all K pinholes, then hm (r) is appreciable over K cone-like regions through the object. The parameters we would like to estimate are the ideal tube integrals, given by d3 r f (r)tj (r).

In a statement probably attributable to W. L. Rogers, pinholes and coded apertures are simply ways of taking advantage of the available detector space-bandwidth product. 3 show how an increase in either the resolution or the area of the detector can be used to increase the performance of a multiple-pinhole system without multiplexing; if the object has a sparse structure, so that relatively few detector elements receive significant radiation, then further advancement can be achieved with multiplexing.

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